Effects of menopause on trends of serum cholesterol, blood pressure, and body mass index
Effects of menopause on trends of serum cholesterol, blood pressure, and body mass index
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DOI：
10.1161/01.cir.94.1.61
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发表时间：
1996-07-01
期刊：
影响因子：
37.8
通讯作者：
Yano, K
中科院分区：
文献类型：
--
作者：
Akahoshi, M;Soda, M;Yano, K
背景为了阐明绝经对冠状动脉危险因素的影响，我们测定了日本长崎妇女的血清胆固醇(mg/dL)、血压(BP，mm Hg)和体重指数(BMI，kg/m(2))的趋势，并调查了绝经对这些趋势的影响。方法和结果：579名自然绝经妇女(年龄从40.2±3.1岁到57.9±3.1岁)从绝经前9年到绝经后9年的胆固醇、收缩压(SEP)和BMI的趋势；绝经年龄49.4±3.0岁)和134例手术绝经妇女(子宫切除加或不双侧卵巢切除；年龄从34.9±4.5岁到51.7±5.1岁；根据1958年至1989年的资料，以绝经时间为基准线，确定长崎市579例和134例年龄和时间相匹配的男性(年龄分别为40.1±3.1岁~57.8±3.2岁和35.2±4.5岁~51.6±5.0岁)的绝经年龄。虽然男性和女性的胆固醇都有随年龄增长的趋势，但在女性中，从自然绝经前3年到自然绝经后1年，以及从手术绝经前1年到手术绝经后1年，胆固醇都显著增加。与自然绝经或手术绝经相比，SBP和BMI没有明显增加。在男性中，自然绝经和手术绝经年龄组的胆固醇、体感诱发电位和体重指数均未见明显升高。结论自然绝经和手术绝经仅对胆固醇有影响，且胆固醇升高比自然绝经早3年，且发生在手术绝经时。
Background To elucidate the impact of menopause on coronary risk factors, we determined the trends of serum cholesterol (mg/dL), blood pressure (BP, mm Hg), and body mass index (BMI, kg/m(2)) and investigated whether menopause affects these trends in women in Nagasaki, Japan,Methods and Results Trends of cholesterol, systolic BP (SEP), and BMI from 9 years before menopause through 9 years after menopause in 579 women with natural menopause (ranging in age from 40.2 +/- 3.1 to 57.9 +/- 3.1 years; age at menopause, 49.4 +/- 3.0 years) and 134 women with surgical menopause (hysterectomy with or without bilateral oophorectomy; ranging in age from 34.9 +/- 4.5 to 51.7 +/- 5.1 years; age at menopause, 42.9 +/- 5.0 years) and those in 579 and 134 age- and time-matched male subjects (ranging in age from 40.1 +/- 3.1 to 57.8 +/- 3.2 years and from 35.2 +/- 4.5 to 51.6 +/- 5.0 years, respectively) in Nagasaki were determined by rearrangement of the data from 1958 to 1989 with time of menopause as the datum line. Although cholesterol tended to increase with age in both sexes, it increased significantly in women from 3 years before natural menopause to 1 year after natural menopause and from 1 year before surgical menopause to 1 year after surgical menopause. SBP and BMI did not exhibit a significant increase in relation to natural or surgical menopause. In male subjects, no significant increase of cholesterol, SEP, or BMI was observed at the age corresponding to natural or surgical menopause.Conclusions Natural menopause and surgical menopause exert an effect only on cholesterol, and an increase in cholesterol precedes natural menopause by 3 years and occurs at the time of surgical menopause.