Molecular characterization of the Aedes aegypti odorant receptor gene family
Molecular characterization of the Aedes aegypti odorant receptor gene family
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DOI：
10.1111/j.1365-2583.2007.00748.x
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发表时间：
2007-10-01
影响因子：
2.6
通讯作者：
Zwiebel, L. J.
中科院分区：
文献类型：
--
作者：
Bohbot, J.;Pitts, R. J.;Zwiebel, L. J.
雌性埃及伊蚊的嗅觉驱动的吸血行为是导致登革热和黄热病的虫媒病毒影响全球超过4000万人的主要传播机制。利用生物信息学分析方法，从A.埃及伊蚊的基因组，可能在这种蚊子的化学感觉感知中起作用。冈比亚按蚊嗅觉亚基因组的比较表明显着分歧的气味受体，反映了高度的进化活动可能导致其在蚊子的生命周期中的关键作用。在幼虫和成人的嗅觉化学感受器的表达分析表明，气味受体触角肾小球的比例不一定是一比一的蚊子。
The olfactory-driven blood-feeding behaviour of female Aedes aegypti mosquitoes is the primary transmission mechanism by which the arboviruses causing dengue and yellow fevers affect over 40 million individuals worldwide. Bioinformatics analysis has been used to identify 131 putative odourant receptors from the A. aegypti genome that are likely to function in chemosensory perception in this mosquito. Comparison with the Anopheles gambiae olfactory subgenome demonstrates significant divergence of the odourant receptors that reflects a high degree of evolutionary activity potentially resulting from their critical roles during the mosquito life cycle. Expression analyses in the larval and adult olfactory chemosensory organs reveal that the ratio of odourant receptors to antennal glomeruli is not necessarily one to one in mosquitoes.