Meningococcal disease at the University of Southampton: outbreak investigation
Meningococcal disease at the University of Southampton: outbreak investigation
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DOI：
10.1017/s0950268899002794
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发表时间：
1999-10-01
影响因子：
4.2
通讯作者：
Stuart, JM
中科院分区：
文献类型：
--
作者：
Gilmore, A;Jones, G;Stuart, JM
1997年10月，南安普顿大学爆发了脑膜炎球菌病。所有六个病例都是住在霍尔斯的一年级学生。病例和携带者菌株的微生物学特征，病例访谈，和脑膜炎球菌携带流行率调查被用来调查疫情。5例为血清群C菌株，1例未经确认。血清分型不能区分菌株，但基因测序允许在爆发中鉴定两种不同的菌株。虽然这些病例彼此都不认识，但其中三人在患病前3-4天的一个晚上参加了同一家夜总会。脑膜炎球菌携带率在大学生的预期范围内（147/587，25%），但没有携带者的爆发菌株被确定在这个样本。研究结果表明，在社会互动程度高的社区，引入高毒力脑膜炎球菌菌株可能会导致传播增强，并出现病例聚集。
In October 1997, an outbreak of meningococcal disease occurred at the University of Southampton. All six cases were first year students living in halls of residence. Microbiological characterization of case and carrier strains, case interviews, and a meningococcal carriage prevalence survey were used to investigate the outbreak. Five cases were due to serogroup C strains, one case was unconfirmed. Serotyping did not distinguish between the strains but gene sequencing permitted identification of two distinct strains in the outbreak. Although none of the cases was known to each other, three had attended the same nightclub one evening 3-4 days before illness. Meningococcal carriage rates in undergraduates were within the range expected (147/587, 25%), but no carriers of outbreak strains were identified in this sample. The findings suggest that in communities with a high degree of social interaction, the introduction of highly virulent meningococcal strains may result in enhanced transmission with clustering of cases.