The tau H2 haplotype is almost exclusively Caucasian in origin
The tau H2 haplotype is almost exclusively Caucasian in origin
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DOI：
10.1016/j.neulet.2004.05.119
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发表时间：
2004-10-21
影响因子：
2.5
通讯作者：
Hardy, J
中科院分区：
文献类型：
--
作者：
Evans, W;Fung, HC;Hardy, J
我们评估了 tau H1/H2 单倍型在公开的参考系列样本中的分布，其中包含大多数种族群体的代表。该分析表明，H2 单倍型可能完全起源于白种人，其在其他种族群体中的边缘出现可能反映了混合。我们从 H2 单倍型的起源和 tau 蛋白病的流行病学角度讨论了这一观察结果。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
We, have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies. (C) 2004 Elsevier Ireland Ltd. All rights reserved.