Bone alkaline phosphatase as a surrogate marker of bone metastasis in gastric cancer patients.
Bone alkaline phosphatase as a surrogate marker of bone metastasis in gastric cancer patients.
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DOI：
10.1186/s12885-016-2415-x
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发表时间：
2016-07-04
期刊：
影响因子：
3.8
通讯作者：
Rha SY
中科院分区：
文献类型：
--
作者：
Lim SM;Kim YN;Park KH;Kang B;Chon HJ;Kim C;Kim JH;Rha SY
在胃癌患者中，骨转移相对罕见，但其事件的早期检测对于防止与骨骼转移相关的并发症，例如疼痛，骨折和化学疗法的妥协。骨转移标记作为胃癌患者骨转移的替代标记的可行性。
这项研究包括58例胃癌患者。骨转移和没有学生的t检验和曼恩 - 惠特尼U检验的骨骼转移。量化关联的强度。
评估了五十八名年龄和性别匹配的患者的骨转换标记，其中29例患者患有骨转移，中位数为62例，有20名（68.9％）和9％（31.1％） ）每组中的骨骼ALP中的女性在患者组中显着高（57.32±46.83 vs. 34.57±21.57，p = 0.037）与ALP，骨钙素，Ca19-9，Ca 72-4呈正相关，并与25（OH）D负相关。特异性为59.4％。
骨骼ALP可能是胃癌患者骨转移的替代标记。
本文的在线版本（DOI：10.1186/S12885-016-2415-X）包含补充材料，可供授权用户使用。
Bone metastasis is relatively uncommon in gastric cancer patients, but its incidence has been rising. Early detection of bone metastasis is important in preventing complications related to bone metastasis such as pain, fracture and the compromise of chemotherapy. In this pilot study, we investigated the feasibility of bone turnover markers as surrogate markers of bone metastasis in gastric cancer patients. Fifty-eight patients with gastric cancer were included in this study. Serum levels of bone alkaline phosphatase (ALP), parathyroid hormone (PTH), 25(OH) D, osteocalcin (OC) and C terminal telopeptide were measured and compared between patients with bone metastasis and those without. Student’s t-test and Mann-Whitney U test were used in comparing two groups, and Spearman’s rank order correlation coefficient was calculated to quantify the strength of the associations. Fifty eight age- and sex-matched patients were evaluated for bone turnover markers, among whom 29 patients had bone metastasis and 29 patients with no bone metastasis. The median age was 62 and there were 20 (68.9 %) males and 9 (31.1 %) females in each group. Bone ALP was significantly higher in the patient group (57.32 ± 46.83 vs. 34.57 ± 21.57, P = 0.037) than control group. Bone ALP was positively associated with ALP, osteocalcin, CA19-9, CA 72–4 and negatively associated with 25(OH) D. According to ROC-curve analysis, at the threshold value of 29.60 μg/L, the sensitivity of bone ALP was 76.7 % and the specificity was 59.4 %. Bone ALP may be a surrogate marker of bone metastasis in gastric cancer patients. More prospective studies are warranted to determine the optimal bone turnover markers in the evaluation of bone metastasis. The online version of this article (doi:10.1186/s12885-016-2415-x) contains supplementary material, which is available to authorized users.