AUTOCRINE OR PARACRINE INFLAMMATORY ACTIONS OF CORTICOTROPIN-RELEASING HORMONE INVIVO
AUTOCRINE OR PARACRINE INFLAMMATORY ACTIONS OF CORTICOTROPIN-RELEASING HORMONE INVIVO
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DOI：
10.1126/science.1925600
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发表时间：
1991-10-18
期刊：
影响因子：
56.9
通讯作者：
CHROUSOS, GP
中科院分区：
文献类型：
--
作者：
KARALIS, K;SANO, H;CHROUSOS, GP
促肾上腺皮质激素释放激素（CRH）是下丘脑-垂体-肾上腺轴的调节因子，也是应激反应的协调者。CRH受体存在于免疫系统的外周部位，并且CRH在体外促进几种免疫功能。在大鼠化学诱导的无菌性炎症实验模型中测试CRH的全身免疫中和作用。腹腔注射兔抗血清CRH引起抑制炎症渗出量和细胞浓度约50%至60%。CRH在炎症区域检测到，但在体循环中未检测到。因此，免疫反应性CRH在外周炎症部位产生，与其全身间接免疫抑制作用相反，它作为自分泌或旁分泌炎症细胞因子。
Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine.