Tumor microenvironment in the brain.
Tumor microenvironment in the brain.
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DOI：
10.3390/cancers4010218
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发表时间：
2012-02-22
期刊：
影响因子：
5.2
通讯作者：
Lorger M
中科院分区：
文献类型：
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作者：
Lorger M
除恶性癌细胞外，肿瘤还含有多种不同的基质细胞，构成肿瘤微环境。其中一些细胞类型为肿瘤生长提供了至关重要的支持，而另一些细胞类型则被认为实际上抑制了肿瘤的进展。肿瘤微环境的组成因肿瘤部位而异。大脑尤其由许多特殊的细胞类型组成，例如小胶质细胞、星形胶质细胞和脑内皮细胞。除了这些脑驻留细胞外，原发性和转移性脑肿瘤也被证明被不同的骨髓来源细胞群浸润。构成肿瘤微环境的不同细胞类型在脑恶性肿瘤进展中的作用尚不清楚。肿瘤微环境已被证明是颅外恶性肿瘤有前途的治疗靶点和诊断标志物。因此，更好地了解大脑中的肿瘤微环境有望有助于开发针对脑肿瘤的改进疗法，由于这些恶性肿瘤的治疗方法匮乏，因此迫切需要这种疗法。这篇综述总结了脑肿瘤和不同基质细胞之间的一些已知相互作用，并讨论了在此背景下潜在的治疗方法。
In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous specialized cell types such as microglia, astrocytes, and brain endothelial cells. In addition to these brain-resident cells, primary and metastatic brain tumors have also been shown to be infiltrated by different populations of bone marrow-derived cells. The role of different cell types that constitute tumor microenvironment in the progression of brain malignancies is only poorly understood. Tumor microenvironment has been shown to be a promising therapeutic target and diagnostic marker in extracranial malignancies. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context.