The Neurobiological Basis of Anxiety and Fear: Circuits, Mechanisms, and Neurochemical Interactions (Part II)
The Neurobiological Basis of Anxiety and Fear: Circuits, Mechanisms, and Neurochemical Interactions (Part II)
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焦虑和恐惧的神经生物学基础：回路、机制和神经化学相互作用（第二部分）
DOI：
10.1177/107385849800400208
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Douglas Bremner
中科院分区：
文献类型：
--
作者：
Dennis;S.;Charney;Christian Grillon;J.;Douglas Bremner
这篇文章是第二部分的神经回路，神经机制，和神经调质，似乎参与焦虑和恐惧状态的审查。第一部分集中在特定的大脑结构，包括杏仁核，蓝斑，海马和各种皮质区域的作用和恐惧条件反射，消退和行为敏化的神经机制，在调解焦虑和恐惧的体征和症状。第二部分试图更好地理解创伤记忆的神经化学介导和压力的神经生物学后果，特别是在生命早期经历的时候。最后，综合这些数据，为理解焦虑症（如恐慌症和创伤后应激障碍）的病理生理学提供基础。神经科学家4：122-132，1998年
This article is Part II of a review of the neuronal circuits, neural mechanisms, and neuromodulators that seem to be involved in anxiety and fear states. Part I focused on the specific brain structures, including the roles of the amygdala, locus coeruleus, hippocampus, and various cortical regions and the neural mechanisms of fear conditioning, extinction, and behavioral sensitization in mediating the signs and symptoms of anxiety and fear. Part II attempts to develop a better understanding of neurochemical mediation of traumatic remembrance and the neurobiological consequences of stress, particularly when experienced early in life. Finally, the data is synthesized to provide a basis for understanding the pathophysiology of anxiety disorders, such as Panic disorder and Posttraumatic Stress Disorder. NEUROSCIENTIST 4:122–132, 1998