A celebration of the 25th anniversary of chromatin-mediated spindle assembly.
A celebration of the 25th anniversary of chromatin-mediated spindle assembly.
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DOI：
10.1091/mbc.e21-08-0400
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发表时间：
2022-02-01
影响因子：
3.3
通讯作者：
Maresca, Thomas J.
中科院分区：
文献类型：
--
作者：
Verma, Vikash;Maresca, Thomas J.
双极纺锤体的形成是细胞分裂过程中染色体可靠分离所必需的。25年前，Rebecca Heald、Eric Karsenti及其同事在他们具有里程碑意义的出版物中对如何实现双极性提供了一个变革性的见解，该出版物描述了一种染色质介导的纺锤体组装途径，其中中心体和动粒被固定。这一发现揭示了双极纺锤体组装是一个自组织过程，其中具有内在极性的微管围绕染色质，并被有丝分裂马达分选成双极结构。在这篇开创性论文发表25周年之际，我们将讨论以前所知道的，我们从那以后所学到的，以及在理解双极纺锤体方面可能存在的问题。
Formation of a bipolar spindle is required for the faithful segregation of chromosomes during cell division. Twenty-five years ago, a transformative insight into how bipolarity is achieved was provided by Rebecca Heald, Eric Karsenti, and colleagues in their landmark publication characterizing a chromatin-mediated spindle assembly pathway in which centrosomes and kinetochores were dispensable. The discovery revealed that bipolar spindle assembly is a self-organizing process where microtubules, which possess an intrinsic polarity, polymerize around chromatin and become sorted by mitotic motors into a bipolar structure. On the 25th anniversary of this seminal paper, we discuss what was known before, what we have learned since, and what may lie ahead in understanding the bipolar spindle.
DOI：
10.1083/jcb.101.3.766
发表时间：
1985-09
期刊：
The Journal of cell biology
影响因子：
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作者：
Mitchison TJ;Kirschner MW
通讯作者：
Kirschner MW