MECHANICAL LOADING HISTORY AND SKELETAL BIOLOGY
MECHANICAL LOADING HISTORY AND SKELETAL BIOLOGY
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DOI：
10.1016/0021-9290(87)90027-3
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发表时间：
1987-01-01
影响因子：
2.4
通讯作者：
CARTER, DR
中科院分区：
文献类型：
--
作者：
CARTER, DR
综述了一个将组织机械应力与骨骼形态发生、生长、再生、维持和退化的许多特征联系起来的综合理论。该理论考虑了构成软骨-骨骨骼上的载荷历史的重复或间歇的机械力。许多机械应力分析的结果表明，局部组织应力历史在控制结缔组织生物学中起着重要作用。机械能在个体发育中的强影响意味着机械能在生殖发育中的强影响。骨骼组织中的机械应力历史与重力直接相关的事实表明，在地球上进化的生命形式与我们的重力场密切相关。
A comprehensive theory which relates tissue mechanical stresses to many features of skeletal morphogenesis, growth, regeneration, maintenance and degeneration is reviewed. The theory considers the repeated or intermittent mechanical forces which constitute the loading history on the chondro-osseous skeleton. The results of numerous mechanical stress analyses indicate that the local tissue stress history plays a major role in controlling connective tissue biology. The strong influence of mechanical energy in ontogenesis implies a comparably strong influence in phylogenesis. The fact that the mechanical stress histories in skeletal tissues are directly related to the force of gravity suggests that the life forms that have evolved on Earth are closely tied to our gravitational field.