THE DOSE-RATE EFFECT REVISITED - RADIOBIOLOGICAL CONSIDERATIONS OF IMPORTANCE IN RADIOTHERAPY
THE DOSE-RATE EFFECT REVISITED - RADIOBIOLOGICAL CONSIDERATIONS OF IMPORTANCE IN RADIOTHERAPY
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DOI：
10.1016/0360-3016(91)90314-t
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发表时间：
1991-11-01
影响因子：
7
通讯作者：
BRENNER, DJ
中科院分区：
文献类型：
--
作者：
HALL, EJ;BRENNER, DJ
辐射生物学和放射治疗中使用的剂量率范围很广，从每天几Gy到不到一秒的数百Gy不等。放射治疗中重要的剂量率范围从约0.1戈瑞/小时到数戈瑞/分钟。在这个范围内，被给定剂量杀死的细胞比例随着剂量率的降低而减少，主要是因为亚致死损伤的修复。在某些细胞系中，观察到逆剂量率效应，即在一个狭窄的剂量率范围内，如果细胞通过周期并停留在放射敏感期G2，则给定剂量的有效性随剂量率的降低而增加。近年来，关于人类细胞的数据已经积累起来。对约40组数据进行了生存曲线参数值和亚致死损伤修复率的分析。这些数据被用来解决与放射治疗相关的三个问题。(1)建议在间质性近距离治疗中使用脉冲照射而不是连续照射。(2)宫颈癌腔内高剂量率治疗与低剂量率治疗的等效性。(3)间质植入物中不同剂量率的等效剂量分析。
A wide range of dose-rates have been used in radiation biology and radiation therapy, extending from a few cGy per day to hundreds of Gy in a fraction of a second. The dose-rate range of importance in radiotherapy extends from about 0.1 Gy/hr to several Gy/min. In this range, the fraction of cells killed by a given dose decreases as the dose-rate is reduced, principally because of the repair of sub-lethal damage. In some cell lines, an inverse dose-rate effect is observed where, over a narrow range of dose-rates, the effectiveness of a given dose increases with decreasing dose-rate if cells move through the cycle and are arrested in G2, which is a radiosensitive phase. In recent years data have accumulated for cells of human origin. About 40 data sets have been analyzed for values of the survival curve parameters and the rate of repair of sub-lethal damage. These data have been used to address three questions of relevance to radiotherapy. (1) The proposal to use pulsed rather than continuous irradiation in interstitial brachytherapy. (2) The equivalence of high dose-rate and low dose-rate intracavitary treatments for carcinoma of the cervix. (3) An analysis of equivalent doses for a range of dose-rates in interstitial implants.