Wingless promotes cell survival but constrains growth during Drosophila wing development
Wingless promotes cell survival but constrains growth during Drosophila wing development
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DOI：
10.1038/ncb1041
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发表时间：
2003-09-01
影响因子：
21.3
通讯作者：
Sanders, AL
中科院分区：
文献类型：
--
作者：
Johnston, LA;Sanders, AL
在动物的发育过程中，器官发育成固定的大小和形状。器官发育通常从一个快速生长阶段开始，随着器官成熟，生长速度逐渐下降(1)，但这两个生长阶段的调控机制尚不清楚。Wnt/Wingless （Wg）蛋白对大多数动物器官的形成至关重要，对发育有多种影响，并被认为可以促进器官生长(2)。在这里，我们报告了与这种观点相反的观点，在果蝇翅膀发育过程中，Wg活性实际上限制了翅膀的生长。此外，我们证明了Wg是翅膀细胞存活所必需的，特别是在翅膀发育的快速生长阶段。我们认为，Wg的细胞生存和生长限制活动可以塑造和划定最终的翅膀大小，作为其整体模式程序的一部分。
During animal development, organs grow to a fixed size and shape. Organ development typically begins with a rapid growth phase followed by a gradual decline in growth rate as the organ matures(1), but the regulation of either stage of growth remains unclear. The Wnt/Wingless (Wg) proteins are critical for patterning most animal organs, have diverse effects on development and have been proposed to promote organ growth(2). Here we report that contrary to this view, Wg activity actually constrains wing growth during Drosophila melanogaster wing development. In addition, we demonstrate that Wg is required for wing cell survival, particularly during the rapid growth phase of wing development. We propose that the cell-survival- and growth-constraining activities of Wg function to sculpt and delimit final wing size as part of its overall patterning programme.