Lewis base activation of Lewis acids: Vinylogous aldol additions of silyl dienol ethers to aldehydes
Lewis base activation of Lewis acids: Vinylogous aldol additions of silyl dienol ethers to aldehydes
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DOI：
10.1055/s-2004-834789
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发表时间：
2004-11-03
期刊：
影响因子：
2
通讯作者：
Heemstra, JR
中科院分区：
文献类型：
--
作者：
Denmark, SE;Heemstra, JR
描述了衍生自简单α，β-不饱和酮的甲硅烷基二烯醇醚的高区域选择性乙烯基双羟醛加成。手性双磷酰胺（R，R）-1活化的四氯化硅催化体系有效地促进了γ-取代和未取代的硅基二烯醇醚与各种醛的加成反应，具有独特的γ-区域选择性和良好的对映体和非对映体选择性。
Highly regioselective vinylogous aldol additions of silyl dienol ethers derived from simple alpha,beta-unsaturated ketones are described. The catalyst system of silicon tetrachloride activated by chiral bisphosphoramide (R,R)-1 effectively promotes the addition of both gamma-substituted and unsubstituted silyl dienol ethers to a variety of aldehydes with exclusive gamma-regioselectivity and good to excellent diastereo- and enantioselectivity.