IRON-BINDING PROTEINS AND INFLUX OF IRON ACROSS THE DUODENAL BRUSH-BORDER - EVIDENCE FOR SPECIFIC LACTOTRANSFERRIN RECEPTORS IN THE HUMAN INTESTINE
IRON-BINDING PROTEINS AND INFLUX OF IRON ACROSS THE DUODENAL BRUSH-BORDER - EVIDENCE FOR SPECIFIC LACTOTRANSFERRIN RECEPTORS IN THE HUMAN INTESTINE
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DOI：
10.1016/0304-4165(79)90377-5
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发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
PETERS, TJ
中科院分区：
文献类型：
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作者：
COX, TM;MAZURIER, J;PETERS, TJ
用体外培养技术检测了一系列同源转铁蛋白样蛋白向人十二指肠黏膜捐献铁的能力。与血清转铁蛋白和卵转铁蛋白相比，只有乳转铁蛋白能够向肠道组织提供铁，但在自体系统中，这种蛋白不能向网状细胞制剂提供铁。对125I标记的乳转铁蛋白和59Fe和125I双标记的乳转铁蛋白的研究表明，完整的蛋白不能进入肠细胞。铁在传递到细胞表面特定的蛋白质结合位点后，可以通过刷状边界运输。
The ability of a range of homologous transferrin-like proteins to donate Fe to pieces of human duodenal mucosa was examined with an in vitro incubation technique. In contrast to serum transferrin and ovotransferrin, only lactotransferrin was able to yield its Fe to intestinal tissue, but in an autologous system this protein was unable to donate Fe to human reticulocyte preparations. Studies with 125I-labeled lactotransferrin and lactotransferrin dual-labelled with 59Fe and 125I indicated that the intact protein is excluded from entry into the enterocytes. Fe may be transported across the brush border after delivery to specific protein binding sites at the cell surface.