CONTINUOUS HYPERTHERMIC PERITONEAL PERFUSION WITH CISPLATIN IN MICE WITH PERITONEAL DISSEMINATION OF B16-MELANOMA
CONTINUOUS HYPERTHERMIC PERITONEAL PERFUSION WITH CISPLATIN IN MICE WITH PERITONEAL DISSEMINATION OF B16-MELANOMA
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DOI：
10.1002/ssu.2980100217
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发表时间：
1994-03-01
期刊：
影响因子：
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通讯作者：
SUGIMACHI, K
中科院分区：
文献类型：
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作者：
OKUYAMA, T;ENDO, K;SUGIMACHI, K
我们设计了小鼠胃癌腹膜播散模型。将B16黑色素瘤细胞注射到C57 BL小鼠的腹腔内，目的是寻找热疗联合顺铂治疗腹膜播散的有效方法。腹腔注射肿瘤细胞后，使用腹膜腔扩张器（PCE）对每只小鼠进行连续热腹膜灌注（CHPP），灌注液中含或不含顺铂，条件为：剖腹手术。根据对照组和治疗组之间的生存时间比较来评估治疗效果。与未治疗对照组的结果相比，接受 CHPP 的组（无论有或没有顺铂）的平均生存期没有延长。需要确定热疗和顺铂的最佳时机和剂量，或添加生化调节剂以增强顺铂的效果，以提高 CHPP 的疗效，无论是否同时给予顺铂。 (C) 1994 年 Wiley-Liss 公司
We designed a model of peritoneal dissemination of gastric cancer in mice. B16 melanoma cells were injected into the peritoneal cavity of C57 BL mice, the object being to search for an effective treatment for peritoneal dissemination, using hyperthermia combined with cisplatin.Following the intraperitoneal administration of tumor cells, each mouse was subjected to continuous hyperthermic peritoneal perfusion (CHPP) using the peritoneal cavity expander (PCE), with or without cisplatin in the perfusate under conditions of laparotomy. Effects of the therapy were evaluated, based on comparison of survival time between the control and treated groups.There was no prolongation of mean survival periods for the groups given CHPP, with or without cisplatin, compared to findings in the no treatment control group. Optimal timing and doses of hyperthermia and cisplatin, or adding biochemical modulators to enhance the effects of cisplatin, will need to be determined to increase the efficacy of CHPP, with or without the concomitant administration of cisplatin. (C) 1994 Wiley-Liss, Inc.