Cervical cytokine responses in women with primary or recurrent chlamydial infection
Cervical cytokine responses in women with primary or recurrent chlamydial infection
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DOI：
10.1089/jir.2006.0132
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发表时间：
2007-03-01
影响因子：
2.3
通讯作者：
Mittal, Aruna
中科院分区：
文献类型：
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作者：
Agrawal, Tanvi;Vats, Vikas;Mittal, Aruna
在人类原发或复发性衣原体感染期间，宫颈细胞因子的同时表达及其受性激素调节的情况知之甚少。采用双抗体夹心ELISA法测定初发或复发性衣原体感染患者和健康对照组宫颈冲洗液和血清中细胞因子(IL-1β、IL-6、IL-10、干扰素-γ和肿瘤坏死因子-α)的浓度，以及血清中的β-雌二醇和孕酮水平。反复感染的妇女宫颈冲洗液中的干扰素-γ水平显著高于初发感染妇女。反复感染时IL-1β水平与孕酮水平呈显著负相关。初发感染妇女的β-雌二醇水平与宫颈IL-10、IL-1β和IL-6浓度呈显著负相关。我们的研究表明，沙眼衣原体在女性生殖道的感染可能受到细胞因子和性激素β-雌二醇和孕酮的协同作用的调节。
Little is known about concurrent expression of cervical cytokines and their regulation by sex hormones during primary or recurrent chlamydial infections in humans. Cytokine (interleukin- 1 beta [IL-1 beta], IL-6, IL-10, interferon-gamma [IFN-gamma], and tumor necrosis factor-alpha [TNF-alpha]) concentrations in cervical washes and serum samples, along with levels of beta-estradiol and progesterone in women with primary or recurrent chlamydial infections and healthy controls, were measured by ELISA. Women with recurrent infections had significantly higher levels of IFN-gamma in cervical washes than did women with primary infections. Significant negative correlation was found between IL-1 beta and progesterone levels during recurrent infections. beta-Estradiol levels in women with primary infections showed significant negative correlations with cervical concentrations of IL-10, IL-1 beta, and IL-6. Our study suggests that Chlamydia trachomatis infection in the female genital tract may be regulated by both the synergistic actions of the cytokines and the sex hormones beta-estradiol and progesterone.