Sleep deprivation and obesity in adults: a brief narrative review.
Sleep deprivation and obesity in adults: a brief narrative review.
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DOI：
10.1136/bmjsem-2018-000392
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发表时间：
2018
影响因子：
4.8
通讯作者：
Martin JL
中科院分区：
文献类型：
--
作者：
Cooper CB;Neufeld EV;Dolezal BA;Martin JL
肥胖和睡眠不足是发达国家普遍存在的两种流行病。全球范围内的发病率一直在稳步上升，尤其是在美国。这篇简短的交流将探讨这两种情况之间的联系，并概述其关系背后的拟议机制。回顾了有关睡眠和肥胖主题的研究，并利用研究结果建立了睡眠时间短与肥胖之间生物联系的理论模型。每晚睡眠时间经常少于 7 小时的人比睡眠时间较多的人更有可能拥有更高的平均体重指数并患上肥胖症。研究表明，实验性睡眠限制与生长素释放肽、盐潴留和炎症标志物水平升高以及瘦素和胰岛素敏感性水平降低有关。肥胖和睡眠不足之间可能存在联系。我们建议进一步研究以阐明潜在的机制。
Obesity and sleep deprivation are two epidemics that pervade developed nations. Their rates have been steadily rising worldwide, especially in the USA. This short communication will explore the link between the two conditions and outline the proposed mechanisms behind their relationship. Studies on the topic of sleep and obesity were reviewed, and findings were used to develop a theoretical model for the biological link between short sleep duration and obesity. Individuals who regularly slept less than 7 hours per night were more likely to have higher average body mass indexes and develop obesity than those who slept more. Studies showed that experimental sleep restriction was associated with increased levels of ghrelin, salt retention and inflammatory markers as well as decreased levels of leptin and insulin sensitivity. There may be a link between obesity and sleep deprivation. We recommend further investigations are to elucidate the potential mechanisms.