Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis
Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis
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丽江 Wikstroemia 地上部分的抗 HIV Tigliane 型二萜类化合物
DOI：
10.1021/acs.jnatprod.1c01195
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发表时间：
2022
影响因子：
5.1
通讯作者：
Li Ning
中科院分区：
文献类型：
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作者：
Zhou Di;Otsuki Kouharu;Zhang Mi;Chen Gang;Bai Zi-Song;Yu Haotian;Kikuchi Takashi;Huang Li;Chen Chin-Ho;Li Wei;Li Ning
tigliane型二萜类化合物由于具有显著的促肿瘤、抗肿瘤和抗hiv活性等生物学效应，在药物开发领域受到广泛关注。为了继续从Wikstroemia lichiangensis中发现新的具有重要生物学意义的二萜类化合物，我们首次对Wikstroemia lichiangensis进行了植物化学研究。结果分离到4个新的（1-4）和1个已知的(5)tigliane型二萜，并通过光谱分析对其结构进行了鉴定。Tiglianes（1 ~ 5）对MT4淋巴细胞HIV-1感染表现出较强的抗hiv活性，ic50值为1.1 ~ 65.4 nM。
Tigliane-type diterpenoids have attracted much attention in drug discovery since they have been reported to exhibit remarkable biological effects, such as tumor-promoting, antineoplastic, and anti-HIV activities. In continuing our efforts to discover novel biologically important diterpenoids fromWikstroemiaspecies,Wikstroemia lichiangensiswas investigated phytochemically for the first time. As a result, four new (1–4) and one known (5) tigliane-type diterpenoid were isolated, and their structures were elucidated by spectroscopic data analysis. Tiglianes (1–5) showed potent anti-HIV activity against HIV-1 infection of MT4 lymphocytes with IC50values of 1.1–65.4 nM.