Morphology Enabled Dipole Inversion (MEDI) from a Single-Angle Acquisition: Comparison with COSMOS in Human Brain Imaging
Morphology Enabled Dipole Inversion (MEDI) from a Single-Angle Acquisition: Comparison with COSMOS in Human Brain Imaging
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DOI：
10.1002/mrm.22816
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发表时间：
2011-09-01
影响因子：
3.3
通讯作者：
Wang, Yi
中科院分区：
文献类型：
--
作者：
Liu, Tian;Liu, Jing;Wang, Yi
磁化率随大脑结构的不同而不同，并提供了对脑组织的化学和分子组成的洞察。然而，从测量的MR信号相位确定任意的磁化率分布是一个具有挑战性的病态逆问题。虽然以前的多方位采样磁化率计算方法(COSMOS)已经从理论和实验上解决了多角度采集的反问题，但在人体上的应用往往是不切实际的。最近，利用形态使能偶极子反演法(MEDI)证明了从单角采集计算大脑磁化率分布的可行性。在这项研究中，我们进一步改进了原始的MEDI方法，通过稀疏量化敏感度图中在震级图像中没有对应边缘的边缘。将改进的MEDI法生成的定量药敏图谱与多方位采样计算药敏结果进行定性和定量比较。结果表明，MEDI与多方位采样的易感性计算高度吻合，MEDI的实用性为临床应用提供了可能。Magn Reson Med 66：777-783,2011。(C)2011年Wiley-Liss，Inc.
Magnetic susceptibility varies among brain structures and provides insights into the chemical and molecular composition of brain tissues. However, the determination of an arbitrary susceptibility distribution from the measured MR signal phase is a challenging, ill-conditioned inverse problem. Although a previous method named calculation of susceptibility through multiple orientation sampling (COSMOS) has solved this inverse problem both theoretically and experimentally using multiple angle acquisitions, it is often impractical to carry out on human subjects. Recently, the feasibility of calculating the brain susceptibility distribution from a single-angle acquisition was demonstrated using morphology enabled dipole inversion (MEDI). In this study, we further improved the original MEDI method by sparsifying the edges in the quantitative susceptibility map that do not have a corresponding edge in the magnitude image. Quantitative susceptibility maps generated by the improved MEDI were compared qualitatively and quantitatively with those generated by calculation of susceptibility through multiple orientation sampling. The results show a high degree of agreement between MEDI and calculation of susceptibility through multiple orientation sampling, and the practicality of MEDI allows many potential clinical applications. Magn Reson Med 66:777-783, 2011. (C)2011 Wiley-Liss, Inc.