Prospects for autoimmune disease - Research advances in rheumatoid arthritis
Prospects for autoimmune disease - Research advances in rheumatoid arthritis
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DOI：
10.1001/jama.285.5.648
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发表时间：
2001-02-07
影响因子：
120.7
通讯作者：
Koopman, WJ
中科院分区：
文献类型：
--
作者：
Koopman, WJ
类风湿性关节炎（RA）是一种常见的慢性炎症性疾病，与进行性关节破坏、严重的发病率和经济负担以及缩短的寿命相关。在理解RA的发病机制方面已经取得了重大进展，并且已经引入了越来越有效的治疗方法，包括抗肿瘤坏死因子α药物。与未来25年的预期进展相比，过去世纪取得的进展将相形见绌，包括疾病易感性和严重程度的遗传基础的描述，严重程度和对治疗反应不同的疾病亚型的遗传定义，以及基于遗传和环境评估的有效个体化治疗的迅速启动。重建手术将变得越来越不必要，由于类风湿关节炎的发病率，经济负担和死亡率将大大降低。
Rheumatoid arthritis (RA) is a common chronic inflammatory disease associated with progressive destruction of diarthrodial joints, substantial morbidity and economic burden, and a shortened lifespan. Significant progress has been made in understanding the pathogenesis of RA, and increasingly effective therapies have been introduced, including anti-tumor necrosis factor alpha agents. Advances made in the past quarter century will pale in comparison to those anticipated for the next 25 years, including delineation of the genetic basis of disease susceptibility and severity, genetic definition of disease subtypes that differ in severity and response to therapy, and prompt initiation of effective individualized treatment based on genetic and environmental assessment. Reconstructive surgery will become increasingly unnecessary and the morbidity, economic burden, and mortality due to RA will be reduced substantially.