Effects of ADH on single-nephron glomerular filtration rates in the avian kidney.
Effects of ADH on single-nephron glomerular filtration rates in the avian kidney.
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ADH 对禽肾单肾单位肾小球滤过率的影响。
DOI：
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发表时间：
1974
影响因子：
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通讯作者：
WH Dantzler
中科院分区：
文献类型：
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作者：
EJ Braun;WH Dantzler
埃尔登·J·布劳恩和威廉·H·丹茨勒。 ADH 对 auian 肾单肾单位肾小球滤过率的影响。是。 J.生理学。 226(1)：1-8。 1974.-在沙漠鹌鹑 Lophortyx gambelii 中研究了 ADH（精氨酸催产素）对全肾肾小球滤过率 (GFR) 以及爬行类 (RT) 和哺乳动物型 (MT) 肾单位单肾单位肾小球滤过率 (SNGFR) 的影响。低剂量（可能是生理剂量）（10 和 50 rig/kg）精氨酸催产素 (AVT) 对平均动脉血压没有影响，但主要由于滤过性 RT 肾单位数量减少而导致总肾 GFR 降低。高剂量（可能是药理学剂量）（200 rig/kg）的 AVT 会导致平均动脉血压升高、降低或双相变化。随着平均动脉压的降低或双相变化，全肾GFR、MT肾单位的SNGFR和滤过性RT肾单位的数量减少。随着平均动脉压的增加，总肾 GFR 降低，MT 肾单位的 SNGFR 增加，RT 肾单位停止滤过。讨论了对 SNGFR 产生这些影响的肾内血流量的可能变化、AVT 和盐负荷对 SNGFR 影响的可能关系，以及滤过性 RT 肾单位数量变化与浓缩能力的可能关系。
BRAUN, ELDON J., AND WILLIAM H. DANTZLER. Effects of ADH on single-nephron glomerular Jiltration rates in the auian kidney. Am. J. Physiol. 226( 1) : 1-8. 1974.-Effects of ADH (arginine vasotocin) on the total-kidney glomerular filtration rate (GFR) and on single-nephron glomerular filtration rates (SNGFR) of reptilian-type (RT) and mammalian-type (MT) nephrons were studied in desert quail, Lophortyx gambelii. Low, probably physiological, doses (10 and 50 rig/kg) of arginine vasotocin (AVT) had no effect on mean arterial blood pressure, but caused reduction in total-kidney GFR primarily as a result of the decrease in the number of filtering RT nephrons. High, probably pharmacological, doses (200 rig/kg) of AVT produced increases, decreases, or biphasic changes in mean arterial blood pressure. With decreases or biphasic changes in mean arterial blood pressure, total-kidney GFR, SNGFR of MT nephrons, and the number of filtering RT nephrons decreased. With increases in mean arterial pressure, total-kidney GFR decreased, SNGFR of MT nephrons increased, and RT nephrons ceased filtering. The possible changes in intrarenal blood flow responsible for these effects on SNGFR, the possible relationship of effects of AVT and salt load on SNGFR, and the possible relationship of changes in the number of filtering RT nephrons to concentrating ability are discussed.