Patterns of ethnic diversity among the genes that influence AIDS.
Patterns of ethnic diversity among the genes that influence AIDS.
复制标题
影响艾滋病的基因中的种族多样性模式。
DOI：
10.1093/hmg/ddh075
复制
发表时间：
2004
影响因子：
3.5
通讯作者：
O'Brien,StephenJ
中科院分区：
文献类型：
--
作者：
Winkler,Cheryl;An,Ping;O'Brien,StephenJ
Although HIV-1/AIDS emerged late in the last century, more than 42 million individuals have been infected and 25 million have died worldwide, making AIDS, like malaria, a strong selective force for disease-associated genetic factors. Many of the genes that mediate immune response or that are co-opted by HIV-1 for completion of its lifecycle show differences in allele frequencies, as a result of drift, migration or selection. Here we show that the majority of AIDS candidate genes and AIDS restriction genes show significant differences in allele frequencies, possibly the result of historic selective pressures. These genes are undergoing present day natural selection in populations with high AIDS prevalence.
