Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin.
Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin.
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DOI：
10.1100/tsw.2003.42
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发表时间：
2003-06-09
影响因子：
--
通讯作者：
Chaplin DD
中科院分区：
文献类型：
--
作者：
Grayson MH;Chaplin DD
T和B细胞相互作用被认为在体液免疫应答的产生中是最重要的。这些相互作用被认为发生在次级淋巴器官中。其中最大的是脾脏。虽然淋巴细胞迁移到其他次级淋巴器官的途径已被解开，但对T和B细胞迁移到脾脏的了解甚少。我们报道过继转移的T淋巴细胞比B淋巴细胞更迅速地出现在脾脏的淋巴区室中。事实上，到1.4小时，脾中转移的T淋巴细胞有一半出现在白色髓内。B淋巴细胞需要近4.3小时才能达到相同的积累水平。此外，T淋巴细胞的到来是岩藻依聚糖敏感的，而B细胞不受这种多糖的影响。最后，我们表明，无论是L-，E-，或P-选择素似乎发挥了重要作用的淋巴细胞在白色纸浆的积累。）
T and B cell interactions are thought to be of prime importance in the generation of a humoral immune response. These interactions are thought to take place in the secondary lymphoid organs. The largest of which is the spleen. While the pathways involved in lymphocyte migration into other secondary lymphoid organs have been unraveled, very little is understood about T and B cell migration to the spleen. We report that adoptively transferred T lymphocytes appear more rapidly within the lymphoid compartment of the spleen than do B lymphocytes. Indeed, half of the transferred T lymphocytes in the spleen appear within the white pulp by 1.4 hours. B lymphocytes take nearly 4.3 hours to achieve the same level of accumulation. In addition, T lymphocyte arrival is fucoidan sensitive, while B cells are not affected by this polysaccharide. Finally, we show that neither L-, E-, or P-selectin appears to play a significant role in the accumulation of lymphocytes in the white pulp.)