Various types of HIV mixed infections in Cameroon
Various types of HIV mixed infections in Cameroon
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DOI：
10.1006/viro.1998.9141
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发表时间：
1998-05-25
期刊：
影响因子：
3.7
通讯作者：
Kaptué, L
中科院分区：
文献类型：
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作者：
Takehisa, J;Zekeng, L;Kaptué, L
为了评估艾滋病毒混合感染的发病率，以及澄清艾滋病毒在中非的分子流行病学，我们调查了43个艾滋病毒从211喀麦隆AC，ARC，艾滋病患者在1994年和1995年。对部分pol区和部分env区进行了分子遗传学分析。43例标本中，A亚型28例（65%），B亚型1例（2%），D亚型2例（5%），F亚型3例（7%），O型2例（5%）。在其余7份标本中，3份为HIV-1亚型A和C、HIV-1亚型C和F以及HIV-2亚型A和HIV-1亚型A的混合感染; 1份为HIV-1亚型A和D以及高度分化的O组的混合感染（三重感染）;另外3份似乎由嵌合基因组（A/G、A/E和B/A重组体）组成。这些数据表明，各种类型的混合感染，如HIV-1 M组不同亚型之间、HIV-1和HIV-2之间，甚至HIV-1 O组和M组之间的混合感染，被确认的频率相当高（约10%）。混合感染在有更多种类的HIV-1亚型流行的地方特别重要，因为它导致亚型间重组产生新的遗传多样性。(C)北京：科学出版社.
In order to assess the incidence of HIV mixed infection as well as to clarify the molecular epidemiology of HIV in central Africa, we investigated 43 HIVs obtained from 211 Cameroonian AC, ARC, and AIDS patients in 1994 and 1995. Part of the pol region and part of the env region were phylogenetically analyzed. The genotypes observed were varied: of 43 specimens, 28 (65%) were subtype A, 1 (2%) was subtype B, 2 (5%) were subtype D, 3 (7%) were subtype F,and 2 (5%) were group O. Of the remaining 7 specimens, 3 were mixed infections with HIV-1 subtypes A and C, HIV-1 subtypes C and F, and HIV-2 subtype A and HIV-1 subtype A; 1 was a mixed infection with HIV-1 subtypes A and D and the highly divergent group O (triple infection); another 3 appeared to consist of mosaic genomes (A/G, A/E, and B/A recombinant). These data show that various types of mixed infection, such as between different subtypes of HIV-1 group M, between HIV-1 and HIV-2, and even between HIV-1 groups O and M, were confirmed at a rather high frequency (approximately 10%). The mixed infection is particularly significant where there is a greater variety of HIV-1 subtypes circulating, since it results in new genetic diversity generated by intersubtype recombination. (C) 1998 Academic Press.