Degradable Polymer Stars Based on Tannic Acid Cores by ATRP
Degradable Polymer Stars Based on Tannic Acid Cores by ATRP
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DOI：
10.3390/polym11050752
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发表时间：
2019-05-01
期刊：
影响因子：
5
通讯作者：
Matyjaszewski, Krzysztof
中科院分区：
文献类型：
--
作者：
Cuthbert, Julia;Yerneni, Saigopalakrishna S.;Matyjaszewski, Krzysztof
为了减少塑料环境污染和废物积累，可降解聚合物至关重要。本文对天然产物单宁酸进行改性，使其成为高分子星星核。采用原子转移自由基聚合（ATRP）引发剂对单宁酸进行了改性，并用H-1 NMR、FT-IR和XPS对改性产物进行了表征。通过光诱导ATRP法制备了聚甲基丙烯酸甲酯（PMMA）或聚（低聚环氧乙烷甲基丙烯酸酯）（摩尔质量M-w = 300 g/mol）（P（OEO（300）MA））的25臂星形聚合物。在温和的碱性条件下，通过酚酯裂解连接到核的聚合物星星臂来降解聚合物星。通过凝胶渗透色谱法（GPC）分析降解之前和之后的星状物。对P（OEO（300）MA）星和相应的降解聚合物进行细胞毒性试验，发现在试验浓度下无毒性。
Degradable polymers are crucial in order to reduce plastic environmental pollution and waste accumulation. In this paper, a natural product, tannic acid was modified to be used as a polymer star core. The tannic acid was modified with atom transfer radical polymerization (ATRP) initiators and characterized by H-1 NMR, FT-IR, and XPS. Twenty-five arm polymer stars were prepared by photoinduced ATRP of poly(methyl methacrylate) (PMMA) or poly(oligo(ethylene oxide) methacrylate) (molar mass M-w = 300 g/mol) (P(OEO(300)MA)). The polymer stars were degraded by cleaving the polymer star arms attached to the core by phenolic esters under mild basic conditions. The stars were analyzed before and after degradation by gel permeation chromatography (GPC). Cytotoxicity assays were performed on the P(OEO(300)MA) stars and corresponding degraded polymers, and were found to be nontoxic at the concentrations tested.