Evolution and Spread of Ebola Virus in Liberia, 2014-2015.
Evolution and Spread of Ebola Virus in Liberia, 2014-2015.
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DOI：
10.1016/j.chom.2015.11.008
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发表时间：
2015-12-09
影响因子：
30.3
通讯作者：
Palacios G
中科院分区：
文献类型：
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作者：
Ladner JT;Wiley MR;Mate S;Dudas G;Prieto K;Lovett S;Nagle ER;Beitzel B;Gilbert ML;Fakoli L;Diclaro JW 2nd;Schoepp RJ;Fair J;Kuhn JH;Hensley LE;Park DJ;Sabeti PC;Rambaut A;Sanchez-Lockhart M;Bolay FK;Kugelman JR;Palacios G
2013年至今的西非埃博拉病毒(EVD)疫情是有记录以来规模最大的一次，报告病例为2.8万例。埃博拉病毒(EBOV)基因组测序在整个疫情中发挥了重要作用；然而，从受影响第二严重的国家利比里亚的患者身上确定的序列相对较少。在这里，我们报告了利比里亚疫情第二波的140个EBOV基因组序列，并结合之前发表的来自整个西非疫情的782个序列进行了分析。虽然埃博夫病毒很明显早期多次传入利比里亚，但利比里亚大多数埃博拉病毒病例符合单一传入，然后是在该国境内传播和多样化。埃博拉病毒在利比里亚境内广泛传播，从利比里亚重新传入是几内亚埃博拉病毒疫情继续爆发的重要来源。总体而言，几乎没有证据表明EBOV对人类宿主的增量适应。
The 2013–present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.