A Case of Brain Abscess Caused by Medication-Related Osteonecrosis of the Jaw.
A Case of Brain Abscess Caused by Medication-Related Osteonecrosis of the Jaw.
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DOI：
10.1155/2016/7038618
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发表时间：
2016
影响因子：
0.8
通讯作者：
Bukawa H
中科院分区：
文献类型：
--
作者：
Yamagata K;Nagai H;Baba O;Uchida F;Kanno N;Hasegawa S;Yanagawa T;Bukawa H
由药物相关性颌骨骨坏死（MRONJ）引起的脑水肿的报告非常罕见。我们在这里提出的情况下，76岁的男子与终末期前列腺癌和脑脓肿造成的MRONJ在上颌骨。患者接受唑来膦酸和地舒单抗治疗骨转移。对于脑脓肿，基于头孢曲松和甲硝唑的抗生素方案和死骨切除术有助于成功的结果。如果上颌MRONJ延伸到上颌窦，应考虑主动切除感染骨，以防止感染扩散到上颌窦以外，进入筛窦和大脑。
Reports of brain abscesses caused by medication-related osteonecrosis of the jaw (MRONJ) are very rare. We here present the case of a 76-year-old man with terminal-stage prostatic carcinoma and a brain abscess caused by MRONJ at the maxilla. The patient had been treated with zoledronic acid and denosumab for bone metastasis. For the brain abscess, an antibiotic regimen based on ceftriaxone and metronidazole and a sequestrectomy contributed to a successful outcome. In the case of maxillary MRONJ extending to the maxillary sinus, active resection of the infected bone should be considered to prevent the spread of the infection beyond the maxillary sinus, into the ethmoid sinus, and into the brain.