Extracellular Vesicles: Unique Intercellular Delivery Vehicles.
Extracellular Vesicles: Unique Intercellular Delivery Vehicles.
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DOI：
10.1016/j.tcb.2016.11.003
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发表时间：
2017-03
影响因子：
19
通讯作者：
Weaver AM
中科院分区：
文献类型：
--
作者：
Maas SLN;Breakefield XO;Weaver AM
细胞外囊泡是一种由膜结合的载体组成的异质集合体，含有复杂的物质，包括蛋白质、脂质和核酸。虽然EV的释放以前被认为只是一种丢弃非功能性细胞成分的机制，但越来越多的证据表明EV是细胞间甚至生物体间通信的关键参与者。EV赋予稳定性，并可以将其货物导向特定的细胞类型。EV货物似乎也以组合方式向其他细胞传达指令。本次审查将集中在EV生物发生，释放和吸收领域的最新研究结果和知识差距。此外，我们强调了EV货物控制基本细胞功能的例子，包括运动和极化，免疫反应和发育，以及导致疾病，如癌症和神经变性。
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers with complex cargos, including proteins, lipids and nucleic acids. While release of EVs was previously thought to be only a mechanism to discard nonfunctional cellular components, increasing evidence implicates EVs as key players in intercellular and even interorganismal communication. EVs confer stability and can direct their cargoes to specific cell types. EV cargoes also appear to act in a combinatorial manner to communicate directives to other cells. This review will focus on recent findings and knowledge gaps in the area of EV biogenesis, release, and uptake. In addition, we highlight examples whereby EV cargoes control basic cellular functions, including motility and polarization, immune responses, and development, as well as contribute to diseases, such as cancer and neurodegeneration.