Transferable tetracycline resistance in Listeria monocytogenes from food in Italy
Transferable tetracycline resistance in Listeria monocytogenes from food in Italy
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DOI：
10.1099/0022-1317-51-7-564
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发表时间：
2002-07-01
影响因子：
3
通讯作者：
Aureli, P
中科院分区：
文献类型：
--
作者：
Pourshaban, M;Ferrini, AM;Aureli, P
以诺卡氏李斯特菌52p tet(R)为对照，研究了最近从食品中分离的两株单核细胞增多性李斯特菌对四环素类药物的耐药机制。四环素耐药性从3个菌株接合转移到伊万诺韦乳杆菌，从1个分离株和对照菌株转移到粪肠球菌。分子分析证实了TET决定簇在染色体上的位置，在所有病例中都被确认为TETM。这些研究首次表明，食品中的单核细胞增多性李斯特菌可能是四环素抗性基因的来源，能够传播到其他微生物。
Mechanisms of tetracycline resistance were investigated in two recent Listeria monocytogenes isolates from food, with L. innocua 52P tet(r) as a control. Tetracycline resistance was transferred conjugatively from all three strains to L. ivanovii and from one isolate and the control to Enterococcus faecalis. Molecular analysis demonstrated a chromosomal location for the tet determinant, which was identified as tetM in all cases. These studies are the first to show that L. monocytogenes from food could be a source of tetracycline resistance genes able to spread to other micro-organisms.