Paternal age and delivery before 32 weeks
Paternal age and delivery before 32 weeks
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DOI：
10.1097/01.ede.0000219740.54796.18
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发表时间：
2006-07-01
期刊：
影响因子：
5.4
通讯作者：
Wilcox, Allen J.
中科院分区：
文献类型：
--
作者：
Basso, Olga;Wilcox, Allen J.
背景：高龄父亲与早期早产（32 周前）有关。方法：我们分析了 1995 年至 2000 年（不包括加利福尼亚州）美国出生证明中记录的白人、非西班牙裔初产妇的活产情况。我们检查了 2,509,012 名 20 至 34 岁已婚女性的怀孕情况，排除了未婚女性，因为父亲年龄数据缺失的比例很高。我们根据排除不可能的出生体重后的临床妊娠估计来定义结果，因为基于末次月经的估计在妊娠早期特别容易出错。结果：父亲年龄较大与早期早产风险增加无关。对于 50 岁或以上的父亲，对于 20 至 24 岁的女性，最高估计比值比为 1.3（95% 置信区间为 0.6-2.8）。结论：这些美国数据并不支持高龄父亲与 32 周前分娩之间的关联。
Background: Advanced paternal age has been linked to early preterm delivery (before 32 weeks).Methods: We analyzed live births from white, non-Hispamic primiparas recorded in U.S. birth certificates from 1995 to 2000 (excluding California). We examined 2,509,012 pregnancies of married women 20 to 34 years old, excluding unmarried women due to the high fraction of missing data on father's age. We defined the outcome according to the clinical estimate of gestation after excluding unlikely birth weights, because the estimate based on last menstrual period is particularly prone to errors at early gestations.Results: Older paternal age was not associated with increased risk of early preterm delivery. The highest estimated odds ratio among fathers 50 years or older was 1.3 (95% confidence interval 0.6-2.8) among women 20 to 24 years old.Conclusions: These U.S. data do not support an association between advanced paternal age and delivery before 32 weeks.