Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
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DOI：
10.1016/j.bmcl.2009.01.094
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发表时间：
2009-03-15
影响因子：
2.7
通讯作者：
Cheung, Mui
中科院分区：
文献类型：
--
作者：
Emmitte, Kyle A.;Adjebang, George M.;Cheung, Mui
一系列噻吩 PLK1 抑制剂经过优化，通过附加碱性胺官能团来增加溶解度并减少蛋白质结合。通过这些修饰还获得了 PLK1 和 PLK3 之间有趣的选择性。阳离子。 (C) 2009 年，爱思唯尔有限公司出版。
A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modi. cations. (C) 2009 Published by Elsevier Ltd.