Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.
Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.
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小鼠体内巨噬细胞的积累受到鼠白血病病毒低分子量产物的抑制。
DOI：
10.4049/jimmunol.124.6.2900
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发表时间：
1980
影响因子：
4.4
通讯作者：
R. Snyderman
中科院分区：
文献类型：
--
作者：
G. Cianciolo;T. Matthews;D. Bolognesi;R. Snyderman
从Friend、Moloney和Rauscher三种已知的致癌病毒中提取的低m.w.提取物可以抑制小鼠延迟炎症反应部位巨噬细胞的积累。这些蛋白的潜在生物学意义是由它们的效力提示的：当在远离炎症反应的部位注射时，只要1.2 ng的病毒蛋白就能抑制巨噬细胞的聚集（p小于0.02）。15000道尔顿（p15E）的病毒包膜蛋白片段同样被发现抑制巨噬细胞积聚，可能部分代表病毒提取物的活性因子。因此，某些致癌病毒可能通过释放系统性巨噬细胞功能的有效抑制剂来发挥其免疫抑制活性。
Low m.w. extracts from three known oncogenic viruses, Friend, Moloney, and Rauscher, inhibited the accumulation of macrophages at sites of delayed inflammatory reactions in mice. The potential biologic significance of these proteins is suggested by their potency: as little as 1.2 ng of viral protein inhibited (p less than 0.02) macrophage accumulation when injected at a site distant to the inflammatory reaction. A virus envelope protein fraction of 15,000 daltons (p15E) was likewise found to inhibit macrophage accumulation and may in part represent the active factor of the virus extracts. Certain oncogenic viruses may thus exert their immunosuppressive activity by release of potent inhibitors of systemic macrophage function.