DACH1 inhibits the proliferation and invasion of lung adenocarcinoma through the downregulation of peroxiredoxin 3.
DACH1 inhibits the proliferation and invasion of lung adenocarcinoma through the downregulation of peroxiredoxin 3.
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DACH1通过下调过氧化物酶3抑制肺腺癌的增殖和侵袭
DOI：
10.1007/s13277-016-4811-x
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Zhu J;Wu C;Li H;Yuan Y;Wang X;Zhao T;Xu J
在这项研究中，我们发现肺腺癌组织和细胞中 Dachshund 1 (DACH1) 的表达下调，而过氧化物酶 3 (PRX3) 的表达上调。转染 DACH1 可以显着下调靶向肺腺癌细胞中 PRX3 的表达。进一步的实验结果表明，DACH1的过度表达导致肺腺癌细胞体外增殖和侵袭的显着延迟。通过共转染PRX3信使RNA(mRNA)直接上调PRX3可以防止DACH1转染引起的上述改变。此外，在过去几个月我院诊断的36例肺腺癌患者中，较低的DACH1表达与肿瘤直径和肿瘤侵袭显着相关。总之，DACH1可以通过下调PRX3抑制肺腺癌的增殖和侵袭。 DACH1表达降低参与肺癌的发生和发展，可能是肺腺癌的不良预后因素。
In this study, we found the expression of Dachshund 1 (DACH1) is downregulated while peroxiredoxin 3 (PRX3) upregulated in both lung adenocarcinoma tissues and cells. Transfection of DACH1 can significantly downregulate PRX3 expression in targeting lung adenocarcinoma cells. Further experimental results demonstrated the evidence that overexpression of DACH1 resulted in significant retardation of in vitro proliferation and invasion of lung adenocarcinoma cells. Direct upregulation of PRX3 by co-transfection of PRX3 messenger RNA (mRNA) can prevent the above alteration caused by DACH1 transfection. Besides, lower DACH1 expression significantly correlated with tumor diameter and tumor invasion in all the 36 patients diagnosed with lung adenocarcinoma in our hospital during the past months. In conclusion, DACH1 can inhibit the proliferation and invasion of lung adenocarcinoma through the downregulation of PRX3. Decreased expression of DACH1 is involved in the initiation and development of lung cancer, which might be an adverse prognostic factor of lung adenocarcinoma.