Apolipoprotein Mimetic Peptides: An Emerging Therapy against Diabetic Inflammation and Dyslipidemia.
Apolipoprotein Mimetic Peptides: An Emerging Therapy against Diabetic Inflammation and Dyslipidemia.
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DOI：
10.3390/biom11050627
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发表时间：
2021-04-23
期刊：
影响因子：
5.5
通讯作者：
Anantharamaiah GM
中科院分区：
文献类型：
--
作者：
Wolkowicz P;White CR;Anantharamaiah GM
肥胖在美国已达到流行状态，导致2型糖尿病、血脂异常和心血管疾病的增加。许多研究表明，炎症在胰岛素抵抗和糖尿病并发症的发展中起着关键作用。高密度脂蛋白胆固醇水平与人类冠心病呈负相关。HDL的有益作用部分归因于具有抗炎特性的载脂蛋白A-I和E。然而，HDL的功能质量在糖尿病的情况下可能会降低。因此，提高功能性HDL水平是减少炎症和糖尿病并发症的重要目标。载脂蛋白A-I具有八个α-螺旋序列，其中大多数形成A类两亲性螺旋结构。属于这类的肽在几种小鼠模型中抑制动脉粥样硬化形成。基于apoE结构组分的其他肽已显示介导血脂异常小鼠中致动脉粥样硬化脂蛋白的快速清除。在这篇综述中，我们讨论了载脂蛋白模拟肽在改善脂蛋白功能，减轻炎症，逆转胰岛素抵抗和糖尿病动物心脏代谢疾病过程中的疗效。
Obesity has achieved epidemic status in the United States, resulting in an increase in type 2 diabetes mellitus, dyslipidemia, and cardiovascular disease. Numerous studies have shown that inflammation plays a key role in the development of insulin resistance and diabetic complications. HDL cholesterol levels are inversely associated with coronary heart disease in humans. The beneficial effect of HDL is due, in part, to apolipoproteins A-I and E, which possess anti-inflammatory properties. The functional quality of HDL, however, may be reduced in the context of diabetes. Thus, raising levels of functional HDL is an important target for reducing inflammation and diabetic complications. Apo A-I possesses eight alpha-helical sequences, most of which form class A amphipathic helical structures. Peptides belonging to this class inhibit atherogenesis in several mouse models. Additional peptides based on structural components of apoE have been shown to mediate a rapid clearance of atherogenic lipoproteins in dyslipidemic mice. In this review, we discuss the efficacy of apolipoprotein mimetic peptides in improving lipoprotein function, reducing inflammation, and reversing insulin resistance and cardiometabolic disease processes in diabetic animals.
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DOI：
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发表时间：
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期刊：
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