CONTRASTING DISEASE PATTERNS IN PSORIASIS AND ATOPIC-DERMATITIS
CONTRASTING DISEASE PATTERNS IN PSORIASIS AND ATOPIC-DERMATITIS
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DOI：
10.1007/bf00585919
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发表时间：
1987-01-01
影响因子：
3
通讯作者：
HENSELER, T
中科院分区：
文献类型：
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作者：
CHRISTOPHERS, E;HENSELER, T
在本报告中，我们调查牛皮癣和特应性皮炎（AD）的同时发生以及与传染性皮肤病的关系。在1953年至1983年间住院的29159例患者中，8.5%（2467例）因牛皮癣治疗，1.6%（470例）因阿尔茨海默病治疗。根据两种疾病的发病率，预计有36例（0.14%）患者同时患有牛皮癣和AD。然而，只有2例患者同时出现这两种情况。大约30%的AD患者患有细菌或病毒感染，而这种并发症发生在6.7%的银屑病患者中。此外，48例疱疹性湿疹住院患者中，39例为特应性，无一例为银屑病。数据表明，同一患者同时出现牛皮癣和AD的情况非常罕见，这可能与免疫防御模式的冲突有关。因此，AD患者对外源蛋白的增敏性增加以及对皮肤感染的高易感性与牛皮癣患者的高吞噬细胞反应性形成对比，牛皮癣患者很少同时感染。
In this report we investigate the simultaneous occurrence of psoriasis and atopic dermatitis (AD) as well as the association with infectious skin diseases. Among 29,159 patients hospitalized between 1953 and 1983, 8.5% (2,467 patients) were treated for psoriasis, while 1.6% (470 patients) were hospitalized for AD treatment. On the basis of incidence rates for both diseases, 36 patients (0.14%) with both psoriasis and AD were expected to be seen. However, the two conditions were simultaneously present in 2 patients only. Approximately 30% of the AD patients were suffering from either bacterial or viral infection, while this complication occurred in 6.7% of psoriatics. In addition, among 48 patients hospitalized for eczema herpeticatum 39 were atopics and none was psoriatic. The data demonstrate that the occurrence of psoriasis and AD in one and the same patient is quite rare and this may be related to conflicting immune defense patterns. Thus, increased sensitization against foreign protein together with high susceptibility to cutaneous infection present in AD is in contrast to high phagocyte responsiveness in psoriasis, where concurrent infections are rare.