Intelligent, self-powered, drug delivery systems
Intelligent, self-powered, drug delivery systems
复制标题
DOI：
10.1039/c2nr32600k
复制
发表时间：
2013-01-01
期刊：
影响因子：
6.7
通讯作者：
Sen, Ayusman
中科院分区：
文献类型：
--
作者：
Patra, Debabrata;Sengupta, Samudra;Sen, Ayusman
自推进式纳米/微型马达和泵被认为是下一代药物输送系统，因为载体可以根据特定的生物标志物推动自己（“基于马达”的药物输送）或被输送（“基于泵”的药物输送）到目标。最近，在将纳米/微转运体开发为生物医学应用的概念验证工具方面取得了重大进展。这一审查包括迄今为止在特定地点运输和交付货物的合成纳米/微型马达和泵的设计方面取得的进展。展望未来，我们可以想象有一天，智能机器在人体中导航，执行具有挑战性的任务。
Self-propelled nano/micromotors and pumps are considered to be next generation drug delivery systems since the carriers can either propel themselves ("motor"-based drug delivery) or be delivered ("pump"-based drug delivery) to the target in response to specific biomarkers. Recently, there has been significant advancement towards developing nano/microtransporters into proof-of-concept tools for biomedical applications. This review encompasses the progress made to date on the design of synthetic nano/micromotors and pumps with respect to transportation and delivery of cargo at specific locations. Looking ahead, it is possible to imagine a day when intelligent machines navigate through the human body and perform challenging tasks.