Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.
Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.
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亚急性细菌性心内膜炎中血清调理素、细菌和多形核白细胞的相互作用。
DOI：
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发表时间：
1968
影响因子：
15.9
通讯作者：
Ralph C. Williams
中科院分区：
文献类型：
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作者：
Ronald P. Messner;Throstur Laxdal;P. G. Quie;Ralph C. Williams
用体外定量吞噬系统检测了抗-丙种球蛋白因子对亚急性细菌性心内膜炎患者7S-丙种球蛋白调理蛋白的影响。来自亚急性细菌性心内膜炎和类风湿性关节炎患者的人抗丙种球蛋白因子抑制了7S丙种球蛋白与细菌特异性结合的调理作用。兔抗人丙种球蛋白抗血清具有类似的抗调理作用。抗丙种球蛋白因子的抗调理作用与其增强7S抗体对细菌的凝集作用无关。抗丙种球蛋白因子的抗调理作用和含有溶血活性补体的不稳定血清因子的促进吞噬作用之间存在竞争。
The effect of anti-gamma-globulin factors on 7S gamma-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-gamma-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S gamma-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human gammaG globulin. The antiopsonic effect of anti-gamma-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-gamma-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.