Alternative splicing in the nervous system: An emerging source of diversity and regulation
Alternative splicing in the nervous system: An emerging source of diversity and regulation
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DOI：
10.1016/s0006-3223(03)00375-5
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发表时间：
2003-10-15
影响因子：
10.6
通讯作者：
Irizarry, K
中科院分区：
文献类型：
--
作者：
Lee, CJ;Irizarry, K
选择性剪接正在成为人类基因组功能调节的主要机制。此前被认为是一个不寻常的事件，许多基因组学研究已在40%-60%的人类基因中检测到了它。此外，它似乎对于神经元基因和涉及“信息处理”功能的其他基因至关重要。在这篇综述中，我们将总结选择性剪接对 mRNA 转录本、蛋白质产物、生物功能和人类疾病的影响，重点关注神经精神病学感兴趣的基因。我们还将描述最新的实验方法和数据库资源，可以帮助神经科学家在他们自己的研究中利用选择性剪接。 (C) 2003 年生物精神病学协会。
Alternative splicing is emerging as a major mechanism of functional regulation in the human genome. Previously considered to be an unusual event, it has been detected by many genomics studies in 40%-60% of human genes. Moreover, it appears to be of central importance for neuronal genes and other genes involved in "information processing" functions. In this review, we will summarize alternative splicing's effects on mRNA transcripts, protein products, biological function, and human disease, focusing on genes of neuropsychiatric interest. We will also describe the latest experimental methods and database resources that can help neuroscientists make use of alternative splicing in their own research. (C) 2003 Society of Biological Psychiatry.