Hypodermic-Needle-Like Hollow Polymer Microneedle Array: Fabrication and Characterization
Hypodermic-Needle-Like Hollow Polymer Microneedle Array: Fabrication and Characterization
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DOI：
10.1109/jmems.2014.2307320
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发表时间：
2014-03
影响因子：
2.7
通讯作者：
Po-Chun Wang;S. Paik;Seong-Hyok Kim;M. Allen
中科院分区：
文献类型：
--
作者：
Po-Chun Wang;S. Paik;Seong-Hyok Kim;M. Allen
提出了一种空心聚合物微针阵列，其尖端和管腔模仿传统的皮下注射针，采用紫外光刻和单步微成型技术制造，用于将药物输送到皮肤中。这种 6 × 6 针阵列由 1 毫米高的高纵横比空心微针组成，具有锋利的斜角尖端和直径 150 微米的侧开腔。同时利用二维光刻掩模图案和微模具的形貌来定义斜角尖端的几何形状和内腔的位置。使用切除的猪皮作为基底，对这些皮下注射针状 (HNL) 微针 (MN) 进行机械插入和流体注射表征。 HNL MN 所需的插入力为 0.275 N，与 26 号皮下注射针的 0.284 N 相当。这些结果比我们之前报道的直径相当的锥体尖端 MN 的插入力降低了一个数量级。插入力的减小证实了尖端几何形状是在这些应用中使用 MN 的一个重要因素。用 50 N 的作用力将 HNL MN 压在切除的猪皮肤上后，在光学显微镜下未观察到针断裂。通过 HNL MN 从注射器将染料初步手动注射到切除的猪皮肤中，验证了 HNL MN 的注射功能。 [2013-0219]。
A hollow polymer microneedle array with tips and lumens that mimic conventional hypodermic needles, fabricated using UV lithography, and a single-step micromolding technique, is presented for drug delivery into skin. This 6 × 6 needle array consists of 1-mm tall high-aspect ratio hollow microneedles with sharp beveled tips and 150-μm diameter side-opened lumens. A 2-D lithographic mask pattern and the topography of the micromold are utilized simultaneously to define the geometry of the beveled tip and the position of the lumen. Mechanical insertion and fluidic injection characterization of these hypodermic-needle-like (HNL) microneedles (MNs) were performed using excised porcine skin as a substrate. The required insertion force of an HNL MN is 0.275 N, which is comparable with that of a 26-gauge hypodermic needle, 0.284 N. These results are an order of magnitude reduction in insertion force over pyramidal-tip MNs of comparable diameter previously reported by us. This insertion force reduction confirms that the tip geometry is an important factor in utilization of MNs in these applications. No needle fracture was observed under an optical microscope following the pressing of an HNL MN against excised porcine skin with application force of 50 N. Preliminary manual injection of dye through an HNL MN from a syringe into excised porcine skin verified the injection functionality of HNL MNs. [2013-0219].