Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior.
Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior.
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DOI：
10.1007/s00213-015-3947-5
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发表时间：
2015-08
影响因子：
3.4
通讯作者：
Miczek KA
中科院分区：
文献类型：
--
作者：
Burke AR;Miczek KA
青少年的社会压力和药物滥用之间的联系是仿照青少年雄性大鼠的社会失败，在这个年龄时，社会经验是必不可少的神经行为成熟。我们调查了社会经验和社会失败的压力在青春期的社会行为和可卡因自我管理（CocSelfAd）在成年早期的作用。在出生后第21天（P），我们通过将雄性大鼠成对（PH）或单独（SH）饲养来操纵社会经验。此外，大鼠从P35-44经历社会失败。在PH和SH青少年和PH成人的第一次和最后一次社会失败期间测量社会行为。在评估对新奇事物和可卡因的行为反应（P57-61）后，植入颈静脉内导管并分析CocSelfAd。居民对PH青少年入侵者的侵略性较低，PH成人入侵者。成年人被攻击时顺从和防御，而PH青少年冻结。在反复失败的过程中，青春期PH大鼠增加冻结，而SH大鼠减少冻结。在多次失败后，更长时间的攻击诱导的冻结预测成年后CocSelfAd的升级。PH对照组获得CocSelfAd的速度比PH失败和SH大鼠慢。击败PH大鼠增加CocSelfAd在渐进的比例强化计划，并在24小时连续访问狂欢相比，PH控制和SH击败大鼠。PH大鼠青春期的社会失败导致成年CocSelfAd持续增加。青少年PH大鼠应对攻击适应性增加冻结行为后，反复的社会失败，一项措施，预测CocSelfAd在成年期。
The link between adolescent social stress and substance abuse is modeled in social defeat of adolescent male rats, at an age when social experiences are essential for neurobehavioral maturation. We investigated the role of social experience and social defeat stress during adolescence on social behavior and cocaine self administration (CocSelfAd) in early adulthood. We manipulated social experience by housing male rats in pairs (PH) or singly (SH) on postnatal day (P) 21. In addition, rats were subjected to social defeat from P35-44. Social behavior was measured during the first and last social defeat in PH and SH adolescents and PH adults. After assessing the behavioral response to novelty and cocaine (P57-61), intra-jugular catheters were implanted and CocSelfAd was analyzed. Residents were less aggressive toward PH adolescent intruders compared to PH adult intruders. Adults were submissive and defensive when attacked, whereas PH adolescents froze. In the course of repeated defeats, adolescent PH rats increased freezing, while SH rats decreased freezing. Longer attack-induced freezing after repeated defeats predicted escalated CocSelfAd in adulthood. PH controls acquired CocSelfAd more slowly than PH defeated and SH rats. Defeated PH rats increased CocSelfAd during progressive ratio schedules of reinforcement and during a 24-hour continuous access binge compared to PH controls and SH defeated rats. Social defeat in adolescence of PH rats caused persistent increases in adult CocSelfAd. Adolescent PH rats coped with attacks adaptively by increasing freezing behavior after repeated social defeats, a measure that predicted CocSelfAd in adulthood.