Recent trends in population genetics: more data! More math! Simple models?

Recent trends in population genetics: more data! More math! Simple models?
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群体遗传学的最新趋势:更多数据!

DOI:
10.1093/jhered/esh062
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发表时间:
2004
期刊:
The Journal of heredity
影响因子:
--
通讯作者:
J. Wakeley
J. Wakeley
中科院分区:
--
文献类型:
--
作者:
J. Wakeley

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回顾了群体遗传学的最新发展并将其置于历史背景中。当前和未来的挑战,无论是计算方法还是分析理论,都是开发模型和技术,从多位点 DNA 数据集中提取尽可能多的信息。作为理论问题的一个例子,在一个统一的框架中提出了人口细分与移民的岛屿模型的五种极限形式。这些近似说明了构建基因谱系中迁移和漂移之间的相互作用,其中一些近似在相当复杂的岛屿模型谱系过程和简单得多的非结构化中性合并过程之间建立了联系,这是群体遗传学中大多数推理技术的基础。
Recent developments in population genetics are reviewed and placed in a historical context. Current and future challenges, both in computational methodology and in analytical theory, are to develop models and techniques to extract the most information possible from multilocus DNA datasets. As an example of the theoretical issues, five limiting forms of the island model of population subdivision with migration are presented in a unified framework. These approximations illustrate the interplay between migration and drift in structuring gene genealogies, and some of them make connections between the fairly complicated island-model genealogical process and the much simpler, unstructured neutral coalescent process which underlies most inferential techniques in population genetics.
DOI: 10.1093/genetics/129.2.585
发表时间: 1991
期刊: Genetics
影响因子: 3.3
作者:
Takahata,N
通讯作者: Takahata,N
DOI: --
发表时间: 1991-10
期刊: Genetics
影响因子: 3.3
作者:
M. Slatkin;R. Hudson
通讯作者: M. Slatkin;R. Hudson
基于非编码序列的多位点分析对人类人口统计学的推论。
DOI: 10.1093/genetics/161.3.1209
发表时间: 2002
期刊: Genetics
影响因子: 3.3
作者:
Pluzhnikov,Anna;DiRienzo,Anna;Hudson,RichardR
通讯作者: Hudson,RichardR
DOI: 10.1016/0040-5809(91)90039-i
发表时间: 1991-02-01
影响因子: 1.4
作者:
HEY, J
通讯作者: HEY, J