Recurrence and reinfection-a new paradigm for the management of Ebola virus disease
Recurrence and reinfection-a new paradigm for the management of Ebola virus disease
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DOI：
10.1016/j.ijid.2015.12.011
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发表时间：
2016-02-01
影响因子：
8.4
通讯作者：
Chughtai, Abrar Ahmad
中科院分区：
文献类型：
--
作者：
MacIntyre, C. Raina;Chughtai, Abrar Ahmad
埃博拉病毒病（EVD）是一种尚未得到充分研究的感染，病毒传播和临床病程的许多方面仍不清楚。西非有超过 17000 名埃博拉病毒病幸存者，世界卫生组织的战略重点是管理幸存者以及恢复期病毒持续存在造成的疫情再次爆发的风险。 2014 年疫情爆发后，还记录了幸存者之间的性传播，并且有记录显示幸存者因埃博拉病毒病症状“复发”而重新入院的病例。除了幸存者体内病毒持续存在之外，还有一些证据表明埃博拉病毒“再次感染”。本文综述了埃博拉病毒病复发和再感染的证据及其对流行病控制的影响。 (C) 2015 年作者。由爱思唯尔有限公司代表国际传染病学会出版。
Ebola virus disease (EVD) is an understudied infection and many aspects of viral transmission and clinical course remain unclear. With over 17 000 EVD survivors in West Africa, the World Health Organization has focused its strategy on managing survivors and the risk of re-emergence of outbreaks posed by persistence of the virus during convalescence. Sexual transmission from survivors has also been documented following the 2014 epidemic and there are documented cases of survivors readmitted to hospital with 'recurrence' of EVD symptoms. In addition to persistence of virus in survivors, there is also some evidence for 'reinfection' with Ebola virus. In this paper, the evidence for recurrence and reinfection of EVD and implications for epidemic control are reviewed. (C) 2015 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.