Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder
Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder
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DOI：
10.1016/j.euroneuro.2005.07.005
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发表时间：
2006-02-01
影响因子：
5.6
通讯作者：
Weizman, A
中科院分区：
文献类型：
--
作者：
Green, P;Hermesh, H;Weizman, A
“磷脂假说”将抑郁症的病理生理机制归因于磷脂的多不饱和脂肪酸（PUFA）组成。本研究的目的是确定该假设是否与社交焦虑症（SAD）相关。研究样本包括 27 名未经治疗、非抑郁的 SAD 患者 (DSM-IV) 和 22 名对照者。使用利博维茨社交焦虑量表（LSAS）评估 SAD 的严重程度。通过气液色谱法测量红细胞PUFA浓度。患者中大多数 n-3 PUFA 的浓度较低：18: 3n-3 降低了 32% (p < 0.002)，20: 3n-3 降低了 34%，20: 5n-3 降低了 36%（全部 p < 0.001），22: 6n-3 降低了 18% (p = 0.002)。其他脂肪酸没有观察到显着差异。 n-3 PUFA 水平与 LSAS 评分之间存在显着的负相关。总之，磷脂假说可能适用于 SAD，从而开辟新的治疗选择。红细胞 n-3 PUFA 浓度与 SAD 之间的牢固关系证明了探索相关神经病理生理学机制的合理性。 (c) 2005 Elsevier B.V. 和 ECNR 保留所有权利。
The "phosphotipid hypothesis" attributes a pathophysiotogic rote to the potyunsaturated fatty acid (PUFA) composition of phospholipids in depression. The aim of the present study was to determine whether the hypothesis is relevant to social anxiety disorder (SAD). The study sample consisted of 27 untreated, nondepressed patients with SAD (DSM-IV) and 22 controls. Severity of SAD was assessed with the Liebowitz Social Anxiety Scale (LSAS). Erythrocyte PUFA concentrations were measured by gas-liquid chromatography. Concentrations of most n-3 PUFAs were lower in the patients: 18: 3n-3 by 32% (p < 0.002), 20: 3n-3 by 34%, 20: 5n-3 by 36% (all p < 0.001) and 22: 6n-3 by 18% (p = 0.002). No significant differences were observed in other fatty acids. Significant inverse correlations were obtained between levels of n-3 PUFAs and LSAS scores. In conclusion, the phospholipid hypothesis may apply to SAD, thereby opening new therapeutic options. The robust relationship between tow erythrocyte n-3 PUFA concentrations and SAD justifies exploration of relevant neuropathophysiological mechanisms. (c) 2005 Elsevier B.V. and ECNR All rights reserved.