Drastic reduction in pneumococcal meningitis in children owing to the introduction of pneumococcal conjugate vaccines: Longitudinal analysis from 2002 to 2016 in Japan
Drastic reduction in pneumococcal meningitis in children owing to the introduction of pneumococcal conjugate vaccines: Longitudinal analysis from 2002 to 2016 in Japan
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DOI：
10.1016/j.jiac.2020.11.019
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发表时间：
2021-02-26
影响因子：
2.2
通讯作者：
Ubukata, Kimiko
中科院分区：
文献类型：
--
作者：
Iwata, Satoshi;Takata, Misako;Ubukata, Kimiko
引言：肺炎球菌分离株的特征及其与小儿脑膜炎预后的关系尚不清楚。方法：对2002 - 2016年大规模监测期间的459株肺炎链球菌和25例脑脊液标本进行血清型和青霉素（PEN）耐药基因型分析。此外，基础疾病（n = 251），腹泻（n = 202），和实验室data.Results：脑膜炎病例数急剧下降后，引入7价肺炎球菌结合疫苗（PCV 7）的-53.6%，转换后PCV 13的-70.2%。特别是，这种减少在= 6年时很明显。与预后不良相关的实验室数据为低白色血细胞计数（
Introduction: The characteristics of pneumococcal isolates and their associations with outcomes in pediatric meningitis are unclear. This study aimed to clarify serotypes and resistance genotypes of Streptococcus pneumoniae from children with meningitis and evaluate the patient prognoses and backgrounds.Methods: Large-scale surveillance was conducted from 2002 to 2016 through periods I-V. Serotypes and penicillin (PEN) resistance genotypes were analyzed for pneumococcal isolates (n = 459) and cerebrospinal fluid (CSF) samples (n = 25). Furthermore, underlying diseases (n = 251), prognoses (n = 202), and laboratory data were evaluated.Results: The number of meningitis cases decreased drastically after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) to -53.6% and after switching to PCV13 to -70.2%. In particular, this reduction was apparent at = 6 years. Laboratory data associated with a poor prognosis were low white blood cell count (