Effect of proglumide on rat pancreatic growth.
Effect of proglumide on rat pancreatic growth.
复制标题
丙谷胺对大鼠胰腺生长的影响。
DOI：
10.1152/ajpgi.1985.249.2.g294
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Johnson,LR
中科院分区：
文献类型：
--
作者：
Yamaguchi,T;Tabata,K;Johnson,LR
丙谷氨酰胺是一种谷氨酸衍生物，是胃泌素和胆囊收缩素受体的特异性竞争性抑制剂。因此，它可以阻断胃泌素刺激的酸分泌、胃泌素的营养作用以及cck刺激的平滑肌收缩和腺泡细胞分泌。在目前的研究中，我们已经证明丙烯酰胺（100mg /kg，每天三次）阻断低剂量CCK八肽（300ng /kg，每天三次，持续2天）的营养作用。然而，同样剂量的丙氨酰胺单独给药6天，可显著刺激胰腺生长。丙氨酰胺对高剂量CCK-OP（5微克/千克）连续2天或6天的营养反应没有影响。这些结果表明，给予数天的丙氨酰胺表现为胰腺生长的部分激动剂。
Proglumide, a glutaramic acid derivative, is a specific competitive inhibitor of gastrin and cholecystokinin (CCK) receptors. As such, it blocks gastrin-stimulated acid secretion, the trophic effect of gastrin, and CCK-stimulated smooth muscle contraction and acinar cell secretion. In the current study we have demonstrated that proglumide (100 mg/kg three times per day) blocks the trophic effect of a low dose of CCK octapeptide (300 ng/kg) given three times a day for 2 days. The same dose of proglumide when given alone for 6 days, however, resulted in a significant stimulation of pancreatic growth. Proglumide had no effect on the trophic response to a high dose of CCK-OP (5 micrograms/kg) administered for either 2 or 6 days. These results indicate that given over a period of several days proglumide behaves like a partial agonist of pancreatic growth.