Cerebral blood flow and oxygen consumption in the newborn dog.
Cerebral blood flow and oxygen consumption in the newborn dog.
复制标题
新生狗的脑血流量和耗氧量。
DOI：
10.1152/ajpregu.1978.234.5.r209
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
G. Bowman
中科院分区：
文献类型：
--
作者：
M. Hernández;R. Brennan;R. Vannucci;G. Bowman
用~(133)Xe改良Kty和Schmidt技术，测定新生犬脑血流量(CBF)、CBF对动脉二氧化碳分压变化的反应和脑氧代谢率(CMRO2)。1-7日龄杂种犬瘫痪后，用70%N_2O和30%O_2被动换气。脑血流量是通过分析来自上矢状窦的成对的20微升的动脉和脑静脉血样本得出的。在动脉血二氧化碳分压为36.9+/-3.7Torr，平均动脉压为62+/-10Torr时，脑血流量为23+/-8ml/min/100g，动静脉血氧差平均为5.6vol%，CMRO2为1.13+/-0.30mlO2/min/100g，脑血流量每增加或减少0.58ml/min/100g。我们的结果表明，在新生儿中，基础CBF和CBF对二氧化碳的反应明显低于成人，并与新生儿大脑较低的新陈代谢需求平行。
Cerebral blood flow (CBF), CBF responses to changes in arterial CO2 tension, and cerebral metabolic rate for oxygen (CMRO2) were measured in newborn dogs, by means of a modification of the Kety and Schmidt technique employing 133Xe. Mongrel dogs of 1-7 days of age were paralyzed and passively ventilated with 70% N2O and 30% O2. CBF was derived by analysis of paired serial 20-microliter samples of arterial and of cerebral venous blood from the superior sagittal sinus. At an arterial PCO2 of 36.9 +/- 3.7 Torr and a mean arterial blood pressure of 62 +/- 10 Torr, CBF was 23 +/- 8 ml/min per 100 g. The arteriovenous oxygen content difference averaged 5.6 vol%, and CMRO2 was 1.13 +/- 0.30 ml O2/min per 100 g. CBF increased or decreased by 0.58 ml/min/100 g per Torr change in PCO2. Our results suggest that in the newborn, basal CBF and CBF responses to CO2 are considerably lower than in the adult and parallel the lower metabolic needs of the newborn brain.