Update on human African trypanosomiasis (sleeping sickness)
Update on human African trypanosomiasis (sleeping sickness)
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DOI：
10.1007/s00415-019-09425-7
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发表时间：
2019-09-01
影响因子：
6
通讯作者：
Kennedy, Peter G. E.
中科院分区：
文献类型：
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作者：
Kennedy, Peter G. E.
人类非洲锥虫病（HAT），也被称为昏睡病，是非洲“被忽视的疾病”之一，由锥虫属的原生动物寄生虫感染引起。它通过采采蝇的叮咬传播，使整个撒哈拉以南非洲的7000万人处于危险之中，如果未经治疗或治疗不当，通常是致命的。在这个简短的概述中，概述了这种疾病的一些重要的最新进展。这些涵盖了各个方面，包括降低疾病发病率，新认识到的人体寄生虫贮主部位，疾病结果，新的诊断方法，新的和改进的治疗方法，以及疾病的神经发病机制。
Human African trypanosomiasis (HAT), also known as sleeping sickness, is one of the Africa's 'neglected diseases' and is caused by infection with protozoan parasites of the Trypanosoma genus. Transmitted by the bite of the tsetse fly, it puts 70 million people at risk throughout sub-Saharan Africa and is usually fatal if untreated or inadequately treated. In this brief overview, some important recent developments in this disease are outlined. These cover various aspects including a reduction in disease incidence, newly recognised parasite reservoir sites in humans, disease outcome, novel diagnostic methods, new and improved treatment, and disease neuropathogenesis.