Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve
Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve
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DOI：
10.1016/s0006-8993(98)00685-4
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发表时间：
1998-09-07
期刊：
影响因子：
2.9
通讯作者：
Watkins, LR
中科院分区：
文献类型：
--
作者：
Goehler, LE;Gaykema, RPA;Watkins, LR
外周给药细菌内毒素，一种免疫兴奋剂，诱导迷走神经初级传入神经元的激活证据。为了确定白细胞介素-1 β (IL-1 β)是否是导致这种激活的分子途径的一部分，我们评估了在腹腔注射IL-1 β (2 μ g/kg)后迷走神经初级传入神经元中神经元激活标记物c-Fos的表达。IL-1 β，而不是载体，诱导c-Fos表达，表明IL-1 β可能是从免疫系统到迷走神经，进而到大脑的重要信号。(C) 1998出版Elsevier Science B.V.版权所有
Peripheral administration of bacterial endotoxin, an immune stimulant, induces evidence of activation in vagal primary afferent neurons. To determine whether interleukin-1 beta (IL-1 beta) is part of the molecular pathway leading to this activation, we assessed the expression of the neuronal activation marker c-Fos in vagal primary afferent neurons after intraperitoneal injections of IL-1 beta (2 mu g/kg). IL-1 beta, but not vehicle, induced c-Fos expression, demonstrating that IL-1 beta is likely an important signal from the immune system to the vagus nerve, and thus the brain. (C) 1998 Published by Elsevier Science B.V. All rights reserved.