Meta-analysis: mortality in Crohn's disease
Meta-analysis: mortality in Crohn's disease
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DOI：
10.1111/j.1365-2036.2007.03276.x
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发表时间：
2007-04-15
影响因子：
7.6
通讯作者：
Mayberry, J. F.
中科院分区：
文献类型：
--
作者：
Canavan, C.;Abrams, K. R.;Mayberry, J. F.
目的：进行荟萃分析是发表的文献报告标准化死亡率（SMR）克罗恩病患者从1970年至今。爆炸性的参考文献确定了额外的论文。当两篇论文在不同时间审查同一患者组的死亡率时，使用了后者的出版物。结果在13篇文献中，3篇文献的SMR小于1.0，2篇文献的置信区间大于1.0。所有其他研究报告的死亡率高于一般人群。使用随机效应模型的荟萃分析显示，克罗恩病SMR的汇总估计值为1.52（95% CI：1.32至1.74 [P < 0.0001]）。荟萃回归分析显示，这些患者的SMR略有下降，在过去的30年，但这种下降是没有统计学意义（P = 0.08）。结论评估证据的原始研究和进行荟萃分析显示，年龄调整的死亡风险克罗恩病是超过50%以上，比一般人群。虽然死亡率有所改善，因为条件是第一次认识到，进一步评估的患者研究的队列中包括在这里是必要的，以评估最近的变化，在临床实践中。
Aim: To perform a meta-analysis is of published literature reporting standardized mortality ratios (SMR) for Crohn's patients from 1970 to date.Methods Medline search identified relevant papers. Exploding references identified additional papers. When two papers reviewed mortality of one patient group at different times, the later publication was used. Results Of 13 papers identified, three studies reported SMR below 1.0, two others had confidence intervals including 1.0. All other studies reported mortality higher than the general population. Meta-analysis using a random effects model shows the pooled estimate for SMR in Crohn's disease is 1.52 (95% CI: 1.32 to 1.74 [P < 0.0001]). Meta-regression shows the SMR for these patients has decreased slightly over the past 30 years, but this decrease is not statistically significant (P = 0.08).Conclusion Assessing evidence from original studies and conducting a meta-analysis shows age-adjusted mortality risk from Crohn's disease is over 50% greater than the general population. Whilst mortality has improved since the condition was first recognized, further evaluation of the patients studied in the cohorts included here is necessary to assess more recent changes in clinical practice.