A bio-chemo-mechanical model for cell contractility
A bio-chemo-mechanical model for cell contractility
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DOI：
10.1073/pnas.0605837103
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发表时间：
2006-09-19
影响因子：
11.1
通讯作者：
Evans, Anthony G.
中科院分区：
文献类型：
--
作者：
Deshpande, Vikram S.;McMeeking, Robert M.;Evans, Anthony G.
细胞的收缩性的一般模型，占动态重组的细胞骨架。该模型由三个关键的生物化学过程激发：（i）触发肌动蛋白聚合和肌球蛋白磷酸化的激活信号，（h）肌动蛋白和肌球蛋白张力依赖性组装成应力纤维，以及（iii）产生张力的肌动蛋白和肌球蛋白丝之间的跨桥循环。提出了简单的关系来模拟这些耦合现象和连续模型模拟细胞收缩。该模型能够预测关键的实验建立的特征，包括：（i）减少的细胞产生的力与增加基板的顺应性，（h）细胞形状和边界条件的影响，结构各向异性的发展，和（iii）高浓度的应力纤维在焦点粘连。我们提出了数值例子的一个正方形细胞的四个支持，以证明这些能力。
A general model for the contractility of cells is presented that accounts for the dynamic reorganization of the cytoskeleton. The model is motivated by three key biochemical processes: (i) an activation signal that triggers actin polymerization and myosin phosphorylation, (h) the tension-dependent assembly of the actin and myosin into stress fibers, and (iii) the cross-bridge cycling between the actin and myosin filaments that generates the tension. Simple relations are proposed to model these coupled phenomena and a continuum model developed for simulating cell contractility. The model is capable of predicting key experimentally established characteristics including: (i) the decrease in the forces generated by the cell with increasing substrate compliance, (h) the influence of cell shape and boundary conditions on the development of structural anisotropy, and (iii) the high concentration of the stress fibers at the focal adhesions. We present numerical examples of a square cell on four supports to demonstrate these capabilities.